Research use only

Longevity research

MOTS-c Australia: 20mg and 10mg Research Peptide

MOTS-c Australia orders from Glow Labs come in two freeze-dried sizes, 20mg and 10mg, for laboratory research. It is a 16 amino acid peptide coded not by the cell nucleus but by DNA inside mitochondria. All orders leave Gippsland in Victoria with tracking and reach their Australian destination in 2-3 days.

Size

$140 AUD per vial, plus $10 tracked shipping per order

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Research use only. Not for human consumption.

No account needed
Tracked, 2-3 days
COA on request

Discreet packaging

Plain outer packaging on every order.

Fast delivery, 2-3 days

Orders leave Traralgon in the afternoon during business hours, then travel tracked to your door.

Certificates on request

Certificates of analysis available on request.

Quality guarantee

If a vial arrives damaged, broken or not what you ordered, message us within 7 days with a photo and we'll replace it free.

What it is

Research overview

What MOTS-c is

MOTS-c stands for mitochondrial open reading frame of the 12S rRNA type-c. Its discovery paper in 2015 found a short open reading frame inside mitochondrial DNA that codes for this 16 residue peptide.

Its sequence is MRWQEMGYIFYPRKLR. PubChem gives the formula as C101H152N28O22S2.

Sources: Lee C et al, The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance, Cell Metab, 2015. PubChem compound record: MOTS-c (CID 146675088), US National Library of Medicine.

Questions about MOTS-c?

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What the research has looked at

The 2015 Cell Metabolism paper reported that skeletal muscle appears to be its main target in mice. It linked MOTS-c to the folate pathway and to AMPK, an energy sensing enzyme, and studied mice on high fat diets and ageing mice.

Later reviews cover work on exercise, insulin sensitivity and ageing models. Most data are from cells and rodents, and reviewers say human studies are still early.

Sources: Lee C et al, The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance, Cell Metab, 2015. Zheng Y et al, MOTS-c: a promising mitochondrial-derived peptide for therapeutic exploitation, Front Endocrinol, 2023.

Where MOTS-c sits among mitochondrial peptides

MOTS-c was not the first peptide found in mitochondrial DNA. Humanin, found earlier, showed that short open reading frames there can code for signalling peptides, and the 2015 team searched for more.

That idea, that mitochondria send their own peptide signals to the rest of the cell, is what makes MOTS-c interesting to researchers.

Sources: Lee C et al, The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance, Cell Metab, 2015.

Storage for an oxidation prone sequence

MOTS-c contains two methionines and one tryptophan. Peptide suppliers warn these residues oxidise easily, and that such peptides have a more limited shelf life.

The best defence is a sealed vial kept at -20 °C or colder, shielded from light, with the cap opened only after the vial has warmed up. Avoid keeping it dissolved for long.

Sources: Bachem, Handling and storage guidelines for peptides, Knowledge Center. JPT Peptide Technologies, How to store peptides: best practices for researchers.

Read the research guide

Specification

Product specs

Name	MOTS-c
Sizes	20mg and 10mg
Form	Lyophilised powder
Vial	3 ml glass vial
Cap	Brushed silver-grey
CAS number	1627580-64-6
Formula	C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molar mass	2174.6 g/mol
Sequence	Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Structure	A mitochondrial-derived peptide encoded within the 12S rRNA gene of mitochondrial DNA.
Storage	Freeze it sealed, dark and dry; two methionines and a tryptophan make it prone to oxidation.
Certificate	On request, how to ask
Status	In stock
Use	Laboratory research only

Sources: PubChem compound record: MOTS-c (CID 146675088), US National Library of Medicine. Lee C et al, The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance, Cell Metab, 2015. Bachem, Handling and storage guidelines for peptides, Knowledge Center. JPT Peptide Technologies, How to store peptides: best practices for researchers.

Regulatory status

In Australia

WADA, the World Anti-Doping Agency, named MOTS-c on its 2025 Prohibited List. It sits in group S4, hormone and metabolic modulators, as an example of an AMPK activator.

The list in force from 1 January 2026 still names it in that group.

Glow Labs offers MOTS-c for laboratory research only.

Sources: USADA, Athlete advisory: what's new on the 2025 WADA Prohibited List, 2024. German Sport University Cologne, Institute of Biochemistry, S4 hormones and metabolic modulators (WADA Prohibited List, in force 1 January 2026).

Testing

COA on request

Certificates of analysis are available on request. Ask us on WhatsApp before or after you order.

How certificates work Ask for the COA

How ordering works

How to order

1
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2
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One tap writes your whole order into a WhatsApp message.
3
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We confirm stock and your total, share payment details, then ship tracked.

FAQ

Your questions

What is MOTS-c?

A 16 amino acid peptide encoded by mitochondrial DNA, first reported in 2015.

What is the difference between MOTS-c and SS-31?

MOTS-c is a natural mitochondrial-derived peptide. SS-31 is a synthetic four residue peptide designed to bind cardiolipin in the mitochondrial membrane.

Which MOTS-c sizes are available?

20mg and 10mg vials. Choose the size on this page before adding it to your bag.

How should MOTS-c be stored?

Freeze the sealed vial, keep it dark, and open it only after it has warmed to room temperature. MOTS-c contains two methionines and a tryptophan, which oxidise easily, so limit how often the vial is opened and avoid long storage in solution.

Do you need a prescription for MOTS-c?

MOTS-c is not named in the Poisons Standard, the federal list that sorts substances into schedules such as Schedule 4, prescription only. We checked the version in force from 30 September 2026. A search of the Australian Register of Therapeutic Goods (ARTG) on 26 October 2026 found no product containing MOTS-c. This page does not say what that means for any use outside the lab, because Glow Labs sells MOTS-c for laboratory research only. In sport, WADA bans MOTS-c at all times. Its 2025 and 2026 lists name it in group S4 as an AMPK activator, and so does the 2027 list that takes effect on 1 January 2027.

Sources: Lee C et al, The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance, Cell Metab, 2015. Szeto HH, First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics, Br J Pharmacol, 2014. JPT Peptide Technologies, How to store peptides: best practices for researchers. Bachem, Handling and storage guidelines for peptides, Knowledge Center. Therapeutic Goods (Poisons Standard, October 2026) Instrument 2026 (F2026L01327), in force from 30 September 2026: no entry for MOTS-c, read 26 October 2026, Federal Register of Legislation, Australian Government. Therapeutic Goods Administration, Australian Register of Therapeutic Goods (ARTG) search for MOTS-c, no matching product, searched 26 October 2026. USADA, Athlete advisory: what's new on the 2025 WADA Prohibited List, 2024. German Sport University Cologne, Institute of Biochemistry, S4 hormones and metabolic modulators (WADA Prohibited List, in force 1 January 2026). World Anti-Doping Agency, 2027 Prohibited List, S4.4.1 activators of AMPK, in force 1 January 2027, read 26 October 2026.